This approach can be used to group ligands that form similar binding networks and thus have similar biological properties. We present an application of interaction fingerprints for the clustering of molecular complexes. We propose interaction fingerprint-based similarity as an alternative measure to RMSD to recapitulate complexes with similar interactions but different folding. We present applications of fingeRNAt-generated interaction fingerprints for visual and computational analysis of RNA-ligand complexes, including analysis of interactions formed in experimentally determined RNA-small molecule ligand complexes deposited in the Protein Data Bank. This output format, in turn, enables high-throughput analysis of interaction data using data analysis techniques. Interactions are also encoded and stored as a bioinformatics-friendly Structural Interaction Fingerprint (SIFt)-a binary string where the respective bit in the fingerprint is set to 1 if a particular interaction is present and to 0 otherwise. In addition, detected interactions can be visualized using the associated PyMOL plugin, which facilitates the analysis of medium-throughput molecular complexes. ![]() However, the scope of detected interactions can be easily expanded using a simple plugin system. The program detects nine types of interactions: (i) hydrogen and (ii) halogen bonds, (iii) cation-anion, (iv) pi-cation, (v) pi-anion, (vi) pi-stacking, (vii) inorganic ion-mediated, (viii) water-mediated, and (ix) lipophilic interactions. Here, we introduce fingeRNAt-a software tool for detecting non-covalent interactions formed in complexes of nucleic acids with ligands. However, the availability of bioinformatics tools for nucleic acids is limited. With novel discoveries of functional RNAs and their possible applications, RNAs have gained considerable attention as potential drug targets. Over the last decades, almost all the attention in medicinal chemistry has been directed to protein-ligand binding, and computational tools have been created with this target in mind. If you have any questions, please feel free to email me.Computational methods play a pivotal role in drug discovery and are widely applied in virtual screening, structure optimization, and compound activity profiling. Actually you can wear it but the chlorine from the swimming pool can be damage your jewelry and leave the annoying stain. # Take off your jewelry before you go swimming and sunbathing. After completely dry, store in airtight container or zip lock bag to avoid scratching the jewelry.? ![]() # After wear clean with warm water and mild soap, rinse under running cold water and dry by using a soft cloth to absorb water. # Keep your jewelry in an airtight container or zip lock bag.? It can be easily damage and causing them to look dull by lotions, soaps, hairspray, cologne, perfume, hand wash, dish liquid and skin oils etc. To make your jewelry last a lifetime, you need good care of your pieces. Please allow 5 to 7 days for process your order, check again after few days later it will show the status after we complete your order and shipped We will print out the label to process your order, when you use the tracking number check from USPS it will mention label created, not yet in system. We ship the package by USPS first class mail. Tungsten ring with color plated can be scratch also, some people misunderstand all tungsten jewelry are scratch proof. Tungsten ring extreme hard but can be break when it drop from high level to floor or hit by hard material. Our tungsten jewelry is cobalt free to avoid allergies. Tungsten is a extreme hardness and high resistance to scratching, it is about 10 times harder then 18K gold and twice stronger then steel. I can customized any of my style or your own design engrave in all ring from my store, if you have any of your own design, logo, image want to engrave on the ring, sent to me, I can make for you. All Sale are Final, No return or exchange for custom make item. Please make sure your ring size and text engrave inside the ring. # Text engraving up to 25 character include space. # Tell us the Font style number # and the text you want engrave inside the ring. # Upload your fingerprint image using contact seller message box. # Leave us a clear instruction in the Note when you check out # Ring Size : US Size 7 to 14 include half size. # Material : Tungsten Carbide, Cobalt free. ![]() Make your own personalized fingerprint ring, this is a tungsten carbide ring with beveled edges glossy black two tone with your own fingerprint engraved inside, outside or both side of the ring, high polish finish with actual fingerprint engraved outside of the ring, comfort fit design.
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